黎家 (dr. jia li)-凯发k8娱乐

本实验主要关注类受体激酶（receptor-like protein kinases）介导的植物细胞信号转导途径，正在进行的有以下三个方面的工作，这些工作大都与类受体激酶相关，是类受体激酶工作的延伸与拓展：

1 ）油菜素内酯的信号传递、合成、及代谢途径的分子调控机制 （brassinosteroid signal transduction and homeostasis）: 油菜素内酯是一类重要的植物激素，参与调控植物生长的各个阶段，阻断油菜素内酯的生物合成或信号转导都会使植物变得极其矮小，并表现出雄性不育、推迟衰老、在黑暗培养时呈现出去黄化等的异常表型。油菜素内酯的受体是一个跨膜的亮氨酸富集型受体激酶，它的胞外特定结构域能特意与油菜素内酯相互作用从而启动胞内一系列磷酸化、脱磷酸化反应，把信号一步步传到细胞核中，最终改变基因的表达。在过去的近二十年中，本研究小组利用激活标签遗传学手段成功地分离到多个关键蛋白 ( 比如： brs1 ， bak1 ， atserk1 ， brl1 ， brl3 ， ben1 等 ) ，研究表明它们在油菜素内酯的信号转导、合成、及代谢调控中起重要作用。利用经典遗传学及生物化学手段，本实验室证明了bak1在油菜素内酯信号早期阶段起必不可少的作用。现阶段的工作集中在利用遗传、生化、蛋白组学等方法继续发现参与油菜素内酯信号转导、合成、及代谢调控的新蛋白，并对以往实验室已发现蛋白所参与的具体作用机制作深入细致的探索。在工作中我们也难免会涉及到其他植物激素在调控植物的生长发育及逆境适应方面的功能，如生长素、细胞分裂素及多肽激素等。

2 ）拟南芥类受体蛋白激酶的生物学功能 （functional analyses of lrr-rlks）:细胞与细胞，细胞与环境之间的信号转导是高等植物生长发育的细胞生物学基础，位于细胞表面的受体激酶在信号转导过程中起至关重要的作用，它们通常作为信号转导的原初受体，接受位于细胞间隙的小分子化合物（即所谓的信号分子），信号分子可以来自于周围的植物细胞或环境中的微生物等。过去的近二十年时间里本实验室做了大量的前期工作，克隆了拟南芥基因组中全部223个编码亮氨酸富集型受体蛋白激酶的大多数全长 cdna（gou et al., 2010, bmc genomics），克隆并建立了全部223个lrr-rlk的promoter-gus转基因植株 （wu et al., 2016, molecular plant），对它们在不同发育阶段的组织水平的转录表达进行了详细的研究，对进一步了解它们真正的生物学功能奠定了良好的基础。目前本实验室正在利用各种遗传学、分子生物学及组学手段对223个lrr-rlks中尚未揭示功能的分子开展生物学功能研究，已有多个尚未研究过的lrr-rlks的功能被鉴定到。

3 ）根生物学 （root biology）:对223个lrr-rlks表达图谱的分析发现大多数lrr-rlks在根中表达，表达模式也不尽相同，说明它们在调控根的发育及环境适应中起重要作用。近年来，实验室围绕lrr-rlks如何调控植物根的发育及环境介导的可塑性生长方面做了一些工作，有了一些意想不到的发现。比如，发现一组lrr-rlks， rgis，能作为rgf1的受体参与根尖stem cell niche的维持；另外，发现两个受体激酶mus及mul在调控侧根发育的早期起重要作用；发现有一个受体激酶参与根的向水性生长，并由此发现根尖细胞分裂素的不对称分布是根向水性生长的决定因素。更多的工作还在进行中。

获外部资助的主要科研项目：

1）国家基金委重大研究计划重点项目“tcp类转录因子在调控油菜素内酯生物合成及信号转导中的作用机理”， 90917019，2010.1.1到2013.12.31， 课题负责人：黎家

2）国家基金委重大研究计划集成项目“油菜素内酯生物合成调控的分子机理”，91117008， 2012.1.1到2013.12.31，课题负责人： 黎家

3）科技部国家基础研究发展计划“高等植物蛋白质修饰与降解调控的分子机理研究”项目（项目负责人：谢旗）中的课题之一“植物蛋白的修饰的重要过程与调控机理”，2011cb915401，2011.1.1到2015.12.31, 课题负责人：黎家

4）国家基金委重大研究计划集成项目“bak1调控油菜素内酯信号转导及器官发育的分子机制”，91317311，2014.1.1到2015.12.31，课题负责人: 黎家

5）国家基金委面上项目“两组类受体激酶调控拟南芥根生长发育的分子机理“， 31470380，2015.1.1到2018.12.31

6）国家基金委重点项目 “植物类受体激酶调控根向水性反应的分子机理“，31530005，2016.1.1到2020.12.31，课题负责人：黎家

7）重点国际合作项目“受体激酶rlk68及rlk165调控拟南芥侧根发生的分子机制”，31720103902， 2017.1.1到2021.12.31， 课题负责人：黎家

8)  国家基金委重点项目 “细胞分离素调控植物向水性生长的分子机制”， 32030005，2021.1.1－2025.12.31，课题负责人：黎家

兰州大学第二届研究生“十佳导学团队”（2020）；甘肃省优秀专家（2015）；virginia tech农学与生命科学学院杰出校友奖（2013-2014年度）； 兰州大学“师德标兵”（2013）；国家特聘专家（2012）；科学中国人（2011年）年度人物奖； 甘肃省领军人才（2010年，2014年，2018年）;  兰州大学“萃英”特聘教授（2009）；长江学者特聘教授（2008）；oklahoma 大学青年教师奖（2003）。                                                            

给研究生讲授“plant hormones”（英文）， 给本科生讲授生命科学导读、部分植物生理学课程; 目前指导3名博士后，15名博士研究生、12名硕士研究生。

本课题组每年都有一定名额对外公开招收植物学及细胞生物学方向硕士及博士研究生，欢迎广大优秀学子积极与我联系（lijia@lzu.edu.cn）并报考或保送做我的学生。也热忱欢迎各位有志于植物细胞信号转导研究的年轻学者作为博士后加盟本团队。

publications (* corresponding author):

cao, j., liang, y., yan, t., wang, x., zhou, h., chen, c., zhang, y., zhang, b., zhang, s., liao, j., cheng, s., chu, j., huang, x., xu, d., li, j., deng, x.w., lin, f.* (2022) the photomorphogenic repressors bbx28 and bbx29 integrate light and brassinosteroid signaling to inhibit seedling development in arabidopsis. plant cell doi:10.1093/plcell/koac092

ou, y., tao, b., wu, y., cai, z., li, h., li, m., he, k., gou, x., li, j.* (2022) essential roles of serks in the root meristem growth factor-mediated signaling pathway. plant physiology doi.org/10.1093/plphys/kiac036

wang, w., hu, c., li, x., zhu, y., tao, l., cui, y., deng, d., fan, x., zhang, h., li, j., gou, x.*, yi, j.* (2021) receptor-like cytoplasmic kinases pbl34/35/36 are required for cle peptide-mediated signaling to maintain sam and ram homeostasis in arabidopsis. plant cell doi: 10.1093/plcell/koab315.

fang, y., chang, j., shi, t., luo, w., ou, y., wan, d.*, li, j.* (2021) evolution of rgf/glv/clel peptide hormones and their roles in land plant growth and regulation. international journal of molecular sciences, 22, 13372.

hu, c., zhu, y., cui, y., zeng, l., li, s., meng, f., huang, s., wang, w., kui, h., yi, j., li, j., wan, d., gou, x.* (2021) a cle-bam-cik signaling module controls root protophloem differentiation in arabidopsis. new phytologist, 233(1), 228-296.

zhang, h., li, x., wang, w., li, h., cui, y., zhu, y., kui, h., yi, j., li, j., gou, x.* (2021) serks regulate embryoic cuticle integrity through the tws-gso1/2 singlaing pathway in arabidopsis. new phytologist, 233(1), 313-328.

chang, j., li, j.* (2022) methods to quantify cell division and hormone gradients during root tropisms. in: blancaflor e.b. (eds) plant gravitropism. methods in molecular biology, vol 2368. humana, new york, ny. https://doi.org/10.1007/978-1-0716-1677-2_5

feng, z., shi, h., lv, m., ma, y., li, j.* (2021) protein farnesylation negatively regulates brassinosteroid signaling via reducing bes1 stability in arabidopsis thaliana. journal of integrative plant biology, 63 (7), 1353-1366.

sun, d., fang, x., xiao, c., ma, z., huang, x., su, j., li, j., wang, j., wang, s., luan, s., he, k.* (2021) kinase snrk1.1 regulates nitrate channel slah3 engaged in nitrate-dependent alleviation of ammonium toxicity. plant physiology 186 (1), 731-749.

fang, x., liu, b., shao, q., huang, x., li, j., lun, s.*, and he, k.* (2021) atpiezo plays an important role in root cap mechanotrasdiction. international journal of molecular sciences 22, 467.

ou, y., kui, h., li, j.* (2020) receptor-like kinases in root development: current progress and future directions. molecular plant 14, 166-185.

chen, l., zhao, m., wu, z., chen, s., rojo, e., luo, j., li, p., zhao, l., chen, y., deng, j., cheng, b., he, k., gou, x., li, j., hou, s.* (2020) rna polymerase ii associated proteins regulate stomatal development through directly interacting with the stomatal transcription factors in arabidopsis thaliana. new phytologist 230, 171-189.

wu, y., gao, y., zhan, y., kui, h., liu, h., yan, l., kemmerling, b., zhou, j-m., he, k.*, li, j.* (2020) loss of the common immune coreceptor bak1 leads to nlr-dependent cell death. proc. natl. acad. sci. usa 117(43), 27044-27053.

wei, z. and li, j.* (2020) regulation of brassinosteroid homeostasis in higher plants. frontiers in plant science 11, 583622.

lu, x., shi, h., ou, y., cui, y., chang, j., peng, l., gou, x., he, k., li, j.* (2020) rgf1-rgi1, a peptide-receptor complex, regulates arabidopsis root meristem development via a mpak signaling cascade. molecular plant 13, 1594-1607.

yin, h., li, m., lv, m., hepworth, s.r., li, d., ma, c., li, j.*, wang, s.* (2020) saur15 promotes lateral and adventitious roo development via activating h -atpase and auxin biosynthesis. plant physiology 184(2), 837-851.

liu, j., li, j., shan, l.* (2020) serks. current biology 30, r287-r301.

lv, m. and li, j.* (2020) molecular mechanisms of brassinosteroid-mediated responses to changing environments in arabidopsis. international journal of molecular sciences 21, 2737; doi:10.3390/ijms21082737     

xun, q., wu, y., li, h., chang, j., ou, y., he, k., gou, x., tax, f. e., li, j.* (2020) two receptor-like protein kinases, mustaches and mustaches-like, regulate lateral root development in arabidopsis thaliana, new phytologist 227, 1157-1173.

gou, x. and li, j.* (2020) paired receptor and coreceptor kinases perceive extracellular signals to control plant development. plant physiology 182(4), 1667-1681.

chang, j., li, x., fu, w., wang, j., yong, y., shi, h., ding, z., kui, h., gou, x., he, k., li, j.* (2019) asymmetric distribution of cytokinins determines root hydrotropism in arabidopsis thaliana. cell research 29(12), 984-993.

chen, w., lv, m., wang, y., wang, p., cui, y., li., m., wang, r., gou, x., li., j.* (2019) bes1 is activated by ems1-tpd1-serk1/2-mediated signaling pathway to control tapetum development in arabidopsis thaliana. nature communications 10, 4164.

zhou, y., xun, q., zhang, d., lv, m., ou, y., and li, j.* (2019) tcp transcription factors associate with phytochrome interacting factor 4 and cryptochrome 1 to regulate thermomorphogenesis in arabidopsis thaliana. iscience 15, 600-610.

li, j., li, c. (2019) seventy-year major research progress in plant hormones by chinese scholars (in chinese). sci sin vitae 49, 1227-1281.

li, h., cai, z., wang, x., li, m., cui, y., cui, n., yang, f., zhu, m., zhao, j., du, w., he, k., yi, j., tax, f.e., hou, s., li, j., gou, x.* (2019) serk receptor-like kinases control division patterns of vascular precursors and ground tissue stem cells during embryo development in arabidopsis. molecular plant 12(7), 984-1002.

wu, z.l., chen, l., yu, q., zhou, w.q., gou, x.p., li, j., hou, s.w.* (2019) multiple transcriptional factors control stomata development in rice. new phytologist 223(1), 220-232.

lv, m., li, m., chen, w., wang, y., sun, c., yin, h., he, k., and li, j.* (2018) thermal-enhanced bri1-301 instability reveals a plasma membrane protein quality control system in plants. frontiers in plant science 9, 1620.

cui, y., hu, c., zhu, y., cheng, k., li, x., wei, z., xue, l., lin, f., shi, h., yi, j., hou, s., he, k., li, j., gou, x.* (2018) cik receptor kinases determine cell fate specification during early anther development in arabidopsis. plant cell 30, 2383-2401.

li, j. * (2018) cell signaling leads the way. journal of integrative plant biology 60, 743-744.

wei, z. and li, j.* (2018) receptor-like protein kinases: key regulators controlling root hair development in arabidopsis thaliana. journal of integrative plant biology 60, 841-850.

hu, c., zhu, y., cui, y., cheng, k., liang, w., wei, z., zhu, m., yin, h., zeng, li, xiao, y., lv, m., yi, j., hou, s., he, k., li, j., gou, x.* (2018). a group of receptor kinases are essential for clavata signaling to maintain stem cell homeostasis. nature plants 4, 205-211.

an, z., liu, y., ou, y., li, j., zhang, b., sun, d., sun, y., tang, w.* (2018) regulation of the stability of rgf1 receptor by the ubiquitin-specific proteases ubp12/ubp13 is critical for root meristem maintenance. proc. natl. acad. sci. usa 115(5), 1123-1128.

zhou, y., zhang, d., an, j., yin, h., fang, s., chu, j., zhao, y., and li, j.* (2018) tcp transcription factors regulate shade avoidance syndrome via directly mediating the expression of both phytochrome interacting factors andauxin biosynthetic genes. plant physiology 176(2), 1850-1861.

cheng, x., gou x., yin, h., mysore, k.s., li, j.*, and wen, j.* (2017) functional characterization of brassinosteroid receptor mtbri1 in medicago truncatula. scientific reports 7: 9327.

ou, y., and li, j.* (2017) three divergent approaches identified the same rgf1 receptors in arabidopsis thaliana. sci china life sci 60, 1040-1043.

sun, c., yan, k., han, j-t., tao, l., lv, m-h., shi, t., he, y-x., wierzba, m., tax, f.e., li, j.* (2017) scanning for new bri1 receptor mutations via tilling analysis. plant physiology 174, 1881-1896.

wei, z., yuan,t., tarkowská,d., kim,j., nam,h.g.,novák,o., he, k., gou, x. and li, j.* (2017) brassinosteroid biosynthesis is modulated via a transcription factor cascade of cog1, pif4 and pif5. plant physiology 174, 1260-1273.

gao, y., wu, y., du, j., zhan, y., sun, d., zhao, j., zhang, s., li, j. and he, k.* (2017) both light-induced sa accumulation and eti mediators contribute to the cell death regulated by bak1 and bkk1. frontiers in plant science 8, 622.

chang, j.k., li, j.* (2017) plants use an atypical strategy to perceive strigolactones. chin bull bot 52, 123−127.

sun, c., li, j.* (2017) biosynthesis, catabolism, and signal transduction of brassinosteroids. plant physiology journal 53, 291-307.

wang, h., wei, z., li, j., wang, x. (2017) brassinosteroids. in: li, j., li., c., and smith, s.m. (eds) hormone metabolism and signaling in plants. woodhead publishing, elsevier

wei, z., gou, x., li, j.* (2016) brassinosteroids. in: els. john wiley & sons, ltd: chichester. doi:10.1002/9780470015902.a0020092.pub2

ou, y., lu, x., zi, q., xun, q., zhang j., wu, y., shi, h., wei, z., zhao, b., zhang, x., he, k., gou, x., li, c., li, j.* (2016) rgf1 insensitive 1 to 5, a group of lrr receptor-like kinases, are essential for the perception of root meristem growth factor 1 in arabidopsis thaliana. cell research, 26(6), 686-698.

chen, l., guan, l., qian, p., xu, f., wu, z., wu, y., he, k., gou, x., li, j., and hou, s.* (2016) nrpb3, the third largest subunit of rna polymerase ii, is essential for stomatal patterning and differentiation in arabidopsis. development 143, 1600-1611.

du, j., gao, y., zan, y., zhang, s., wu, y., xiao, y., zou, b., he, k., gou, x., li, g., lin, h., li, j.* (2016) nucleocytoplasmic trafficking is essential for bak1 and bkk1-mediated cell-death control. plant journal 85(4), 520-531.

 zhang, j., yuan, t., duan, x., wei, x., shi, t., li, j., russell, s.d.*, gou, x.* (2016) cis-regulatory elements determine germline specificity and expression level of an isopentenyltransferase gene in sperm cells of arabidopsis. plant physiology 170(3), 1524-1534. 

yue, j., qin, q., meng, s., jin, h., gou, x., li, j., hou, s.* (2016) topp4 regulates the stability of phytochrome interacting factor 5 during photomorphogenesis in arabidopsis. plant physiology 170(3), 1381-1397.

zhao, b., lv, m., feng, z., campbell, t., liscum, e., li, j.* (2016) twisted dwarf 1 associates with brassinosteroid insensitive 1 to regulate early events of the brassinosteroid signaling pathway. molecular plant 9(4), 582-592.

wu, y., xun, q., guo, y., zhang, j., cheng, k., shi, t., he, k., hou, s., gou, x., li, j.* (2016) genome-wide expression pattern analyses of the arabidopsis leucine-rich repeat receptor-like kinases. molecular plant 9(2), 289-300.

wei, z. and li, j.* (2016) brassinosteroid regulates root growth, development, and symbiosis. molecular plant 9(1), 86-100.

wu, w., wu y., gao, y., li, m., yin, h., lv, m., zhao, j., li, j., he, k.* (2015) somatic embryogenesis receptor-like kinase 5 in the ecotype landsberg erecta of arabidopsis is a functional rd lrr-rlk in regulating brassinosteroid signaling and cell death control. frontiers in plant science 6, 852.

shi, t., dimitrov, i., zhang, y., tax, f.e., yi, j., gou, x., li, j.* (2015) accelerated rates of protein evolution in barley grain and pistil biased genes might be legacy of domestification. plant molecular biology 89(3), 253-261.

gao, y., zhang, d., and li, j.* (2015) tcp1 moduates dwf4 expression via directly interacting with the ggnccc motifs in the promoter region of dwf4 in arabidopsis thaliana. journal of genetics & genomics 42(7), 383-392.

guo, x., qin, q., yan, j., niu, y., huang, b., guan, l., li, y., ren, d.,li, j., hou, s.* (2015) type-one protein phosphatase 4 regulates pavement cell interdigitation by modulating pin-formed 1 polarity and trafficking in arabidopsis. plant physiology 167 (3), 1058-1075.

qin, q., wang, w., guo, x., yue, j., huang, y., xu, x., li, j., hou, s.* (2014) arabidopsis della protein degradation is controlled by a type-one protein phosphatase, topp4. plos genetics 10(7):e1004464.

yang, z.r., zhang, c.j., yang, x.j., kun, l.,wu, z.x., zhang, x.y., zheng, w.,xun, q.q., liu, c.l., lu, l.l., yang, z.e., qian, y.y., xu, z.z.,li, c.f., li,j.*, li, f.g.* (2014) pag1, a cotton brassinosteroid catabolism gene, modulates fiber elongation. new phytologist 203, 437-448.

qin, z.x., zhang, x.r., zhang, x., xin, w., li, j., hu, y.x.* (2014) the arabidopsis transcription factor iib-related protein brp4is involved in the regulation of mitotic cell-cycle progression during male gametogenesis. journal of experimental botany 65(9),2521-2531.

he, k., xu, s., li, j.* (2013) bak1 directly regulates brassinosteroid perception and bri1 activation. journal of integrative plant biology 55(12),1264-1270. 

li, j.*, tax, f.e. (2013) receptor-like kinases: key regulators of plant development and defense. journal of integrative plant biology 55(12),1184-1187.

ma, t., wang, j., zhou, g., yue, z., hu, q., chen, y., liu, b., qiu, q., wang, z., zhang, j., wang, k., jiang, d., gou, c., yu, l., zhan, d., zhou, r.., luo, w., ma, h., yang, y., pan, s., fang, d., luo, y., wang, x., wang, g., wang, j., wang, q., lu, x., chen, z., liu, j., lu, y., yin, y., yang, h., abbott, r.j., wu, y., wan, d., li, j., yin, t., lascoux, m., difazio, s.p., tuskan, g.a., wang, j., liu, j.* (2013) genomic insights into salt adaptation in a desert poplar. nature communications 4, 2797.

qian, p., han, b., forestier, e., hu, z., gao, n., lu, w., schaller, h., li, j., hou, s.* (2013) sterols are required for cell fate commitment and maintenance of the stomatal lineage in arabidopsis. the plant journal 74, 1029-1044.

zhao, b. and li, j.* (2012) regulation of brassinosteroid biosynthesis and inactivation. journal of integrative plant biology 54 (10), 746-759.

wen, j.*, li, j., and walker, j.c. (2012) overexpression of a serine carboxypeptidase increases carpel number and seed production in arabidopsis thaliana. food and energy security 1(1), 61-69. 

du, j., yin, h., zhang, s., wei, z., zhao, b., zhang, j., gou, x., lin, h., and li, j.* (2012) somatice embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in arabidopsis thaliana. journal of integrative plant biology  54(6), 388-399.

gou, x. and li, j.* (2012) activation tagging. methods in molecular biology 876, 117-133.

gou, x., yin, h., he, k., du, j., yi, j., xu, s., lin, h., clouse, s.d., li, j.* (2012) genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. plos genetics 8(1): e1002452.

li, j.*, du, j., he, k., and gou, x. (2012) cell death control by receptor kinases in arabidopsis thaliana. in, f.e. tax and b. kemmerling (editors) receptor-like kinases in plants: from development to defense. springer. volume 13, pp79-91.

wei, z-y and li, j.* (2011) receptor kinases mediated brassinosteroid signal transduction in plants. chinese bulletin of life sciences. 23 (11), 1106-1113.

an, j., guo, z., gou, x., li, j.* (2011) tcp1 positively regulates the expression of dwf4 in arabidopsis thaliana. plant signaling & behavior, 6: 1117-1118.

li, j.* (2010) multi-tasking of somatic embryogenesis receptor-like protein kinases. current opinion in plant biolology ,13: 509-514.

guo, z., fujioka, s., blancaflor, e.b., miao, s., gou, x., and li, j.* (2010) tcp1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene dwarf4 in arabidopsis thaliana. plant cell 22, 1161-1173.

yang, h., gou, x., he, k., xi, d., du, j., lin, h., li, j.* (2010) arabidopsis bak1 and bkk1 confer reduced susceptibility to turnip crinkle virus. european journal of plant pathology, 127: 147-156.

gou, x., he, k., yang, h., yuan, t., lin, h., clouse, s.d., li, j.* (2010) genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in arabidopsis thaliana. bmc genomics 11(1):19

li, d., wang, m., xu y.y., luo, w., liu, z.h., li, j., chong, k.* (2009) engineering osbak1 gene as a molecular tool to improve rice architecture for high yield. plant biotechnology journal 7(8): 791-806.

wang, x., kota, u., he, k., blackburn, k., li, j., goshe, m.b., huber, s.c., and clouse, s.d.* (2008) sequential transphosphorylation of the bri1/bak1 receptor kinase pair impacts early events in brassinosteroid signaling. developmental cell 15, 220-235.

he, k., gou, x., powell, r.a., yang, h., yuan, t, guo, z., and li, j.* (2008) receptor-like protein kinases, bak1 and bkk1, regulate a light-dependent cell-death control pathway. plant signaling & behavior 3 (10), 813-815.

clouse, s.d.*, goshe, m.b., huber, s.c. and li, j. (2008) functional analysis and phosphorylation site mapping of leucine-rich repeat receptor-like kinases. in, gk agrawal and r rakwal (eds) plant proteomics: technologies, strategies and applications. john wiley & sons, pp 469-484.

heese, a., hann, d.r., gimenez-ibanex, s., jones, a., he, k., li, j., schroeder, j.i., peck, s.c., rathjen, j.p.* (2007) the receptor-like kinase serk3/bak1 is a central regulator of innate immunity in plants. proc. natl. acad. sci. usa 104, 12217-12222.

he, k., gou, x., yuan, t., lin, h., asami, t., yoshida, s., russell, s.d., li, j.* (2007) bak1 and bkk1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell death pathways. current biology 17, 1109-1115.

yuan, t., fujioka, s., takatsuto, s., matsumoto, s., gou, x.,he, k., russell, s.d., and li, j.* (2007) ben1, a gene encoding a dihydroflavonol 4-reductase (dfr)-like protein, regulates the levels of brassinosteroids in arabidopsis thaliana. the plant journal 51 (2), 220–233.

li, j.* and gou, x. (2007) brassinosteroids. in: encyclopedia of life sciences. john wiley & sons, ltd: chichester http://www.els.net/ [doi: 10.1002/9780470015902.a0020092]

wang, l., xu, y.y., li, j.*, powell, r.a., xu, z.h., and chong, k.* (2007) transgenic rice plants ectopically expressing atbak1 are semi-dwarfed and hypersensitive to 24-epibrassinolide. journal of plant physiology 164(5), 655-664.

zhou, a. and li, j.* (2005) arabidopsis brs1 is an active and secreted serine carboxypeptidase. journal of biological chemistry 280 (42), 35554-35561.

xu, y.y., wang, x.m., li, j., li, j.h., wu, j.s., walker, j.c., xu, z.h., chong, k.* (2005) activation of the wus gene induces ectopic initiation of floral meristems on mature stem surface in arabidopsis thaliana.  plant molecular biology 57 (6), 773-784.

wang, x.f., goshe, m. b., soderblom, e., phinney, b.s., kuchar, j., li, j., asami, t., yoshida, s., huber, s. c., clouse, s. d.* (2005) identification and functional analysis of in vivo phosphorylation sites of the arabidopsis brassinosteroid-insensitive 1 receptor kinase. the plant cell 17(6), 1685-703.

zhou, a., wang, h., walker, j.c., and li, j.* (2004) brl1, a leucine-rich repeat receptor-like protein kinase, is functionally redundant with bri1 in regulating arabidopsis brassinosteroid signaling. the plant journal 40, 399-409.

lee, g., li, j., walker, j.c. and van doren s.r.* (2003) 1h. 13c and 15n resonance assignments of the kinase interacting fha domain of arabidopsis thaliana kinase-associated protein phosphatase.  journal of biomolecular nmr 25, 253-254.

li, j., wen, j., lease, k.a., doke, j.t., tax, f.e. and walker, j.c.* (2002) bak1, an arabidopsis lrr receptor-like protein kinase, interacts with bri1 and modulates brassinosteroid signaling. cell 110, 213-222.

lease, k.a., wen, j., li, j., doke, j.t., liscum, e. and walker, j.c.* (2001) a mutant arabidopsis heterotrimeric g protein b subunit affects leaf, flower and fruit development. the plant cell 13, 2631-2641.

li, j., lease, k.a., tax, f.e. and walker, j.c.* (2001) brs1, a serine carboxypeptidase, regulates bri1 signaling in arabidopsis thaliana. proc. natl. acad. sci. usa 98, 5916-5921.

li, j., lee, g., van doren, s.r. and walker, j.c.* (2000) the fha domain mediates phosphorylation-dependent protein-protein interactions. journal of cell science 113, 4143-4149.

li, j., smith, g.p. and walker, j.c.* (1999) kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. proc. natl. acad. sci. usa 96, 7821-7826.

lin, q., li, j., smith, r.d. and walker, j.c.* (1998) molecular cloning and chromosomal mapping of type one serine/threonine protein phosphatases in arabidopsis thaliana. plant molecular biology 37, 471-481.

li, j., hegeman, c.e., hanlon, w.r., lacy, g.h., denbow, d.m. and grabau, e.a.* (1997) secretion of active recombinant phytase from soybean cell-suspension cultures.  plant physiology 114, 1103-1111.

li, j. and grabau, e.a.* (1996) comparison of somatic embryogenesis and embryo conversion in commercial soybean cultivars. plant cell, tissue organ cult. 44, 87-89.

联系地址 （contact information）:

dr. jia li, school of life sciences, lanzhou university, 222 south tianshui road, lanzhou 730000, people's republic of china. email: lijia@lzu.edu.cn; office phone: 0931-8915662