2007-2009 postdoctoral training, new york university, usa
2001-2007 ph. d., the university of british columbia, canada
1995-1998 m.s., department of biology, lanzhou university, china
1991-1995 b.s., department of biology, lanzhou university, china
2009-present school of life sciences, lanzhou university
1998-2000 department of biology, nanjing university
professor, director
department of zoology and biomedical sciences
school of life sciences
lanzhou university
publications：
for most recent publications, please visit my orcid profile:
xie, w., gong, x.t., cheng, x., cao, j., zhao, j., zhang, h.l. & zhang, s. (2021) limpid: a versatile method for visualization of brain vascular networks. biomaterials science.
yang, y.p., qi, f.j., qian, y.p., bao, x.z., zhang, h.c., ma, b., dai, f., zhang, s.x. & zhou, b. (2021) developing push-pull hydroxylphenylpolyenylpyridinium chromophores as ratiometric two-photon fluorescent probes for cellular and intravital imaging of mitochondrial nqo1. analytical chemistry 93:2385-2393.
li, t., zhao, j., xie, w., yuan, w., guo, j., pang, s., gan, w.b., gomez-nicola, d. & zhang, s. (2021) specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. journal of neuroinflammation 18:81.
hu, g., zhong, m., zhao, j., gao, h., gan, l., zhang, h., zhang, s. & fang, j. (2021) fluorescent probes for imaging protein disulfides in live organisms. acs sensors 6:1384-1391.
roth, s., cao, j., singh, v., tiedt, s., hundeshagen, g., li, t., boehme, j.d., chauhan, d., zhu, j., ricci, a., gorka, o., asare, y., yang, j., lopez, m.s., rehberg, m., bruder, d., zhang, s., gross, o., dichgans, m., hornung, v. & liesz, a. (2021) post-injury immunosuppression and secondary infections are caused by an aim2 inflammasome-driven signaling cascade. immunity.
wang, l., zhu, l., liu, j. & zhang, s. (2020) long-term high-resolution in vivo imaging of cerebral cortical structures following ischemic stroke. biophysics reports 6:127-136.
liu, x., shang, s., chu, w., ma, l., jiang, c., ding, y., wang, j., zhang, s. & shao, b. (2020) astragaloside iv ameliorates radiation-induced senescence via antioxidative mechanism. journal of pharmacy and pharmacology 72:1110-1118.
zhao, j., qu, y., gao, h., zhong, m., li, x., zhang, f., chen, y., gan, l., hu, g., zhang, h., zhang, s. & fang, j. (2020) loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. chemical communications (cambridge, england) 56:14075-14078.
long, y., liu, j., tian, d., dai, f., zhang, s. & zhou, b. (2020) cooperation of esipt and ict processes in the designed 2-(2'-hydroxyphenyl)benzothiazole derivative: a near-infrared two-photon fluorescent probe with a large stokes shift for the detection of cysteine and its application in biological environments. analytical chemistry 92:14236-14243.
gong, x.t., xie, w., cao, j.j., zhang, s., pu, k. & zhang, h.l. (2020) nir-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging. biomaterials science 8:2666-2672.
zhang, s. (2019) microglial activation after ischaemic stroke. stroke and vascular neurology 4:71-74.
ju, f., ran, y., zhu, l., cheng, x., gao, h., xi, x., yang, z. & zhang, s. (2018) increased bbb permeability enhances activation of microglia and exacerbates loss of dendritic spines after transient global cerebral ischemia. frontiers in cellular neuroscience 12:236.
zhu, l., wang, l., ju, f., khan, a., cheng, x. & zhang, s. (2017) reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice. experimental neurology 289:1-8.
zhu, l., wang, l., ju, f., ran, y., wang, c. & zhang, s. (2017) transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures. journal of cerebral blood flow and metabolism 37:2756-2767.
khan, a., ju, f., xie, w., tariq hafeez, m., cheng, x., yang, z., zhu, l., li, t. & zhang, s. (2017) transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice. neuroscience 348:212-227.
wang, c., tao, s., fang, y., guo, j., zhu, l. & zhang, s. (2016) infiltrating cells from host brain restore the microglial population in grafted cortical tissue. scientific reports 6:33080.
li, l., du, y., ju, f., ma, s. & zhang, s. (2016) calcium plays a key role in paraoxon-induced apoptosis in el4 cells by regulating both endoplasmic reticulum- and mitochondria-associated pathways. toxicology mechanisms and methods 26:211-20.
li, t. & zhang, s. (2016) microgliosis in the injured brain: infiltrating cells and reactive microglia both play a role. neuroscientist 22:165-70.
li, d., guo, j., zhou, x., chang, c. & zhang, s. (2016) the complete mitochondrial genome of phrynocephalus helioscopus (reptilia, squamata, agamidae). mitochondrial dna a dna mapp seq anal 27:1846-7.
sun, c.-l., liao, q., li, t., li, j., jiang, j.-q., xu, z.-z., wang, x.-d., shen, r., bai, d.-c., wang, q., zhang, s.-x., fu, h.-b. & zhang, h.-l. (2015) rational design of small indolic squaraine dyes with large two-photon absorption cross section. chemical science 6:761-769.
tang, p., zhang, y., chen, c., ji, x., ju, f., liu, x., gan, w.b., he, z., zhang, s., li, w. & zhang, l. (2015) in vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury. scientific reports 5:9691.
wang, y., wang, q., lv, s. & zhang, s. (2015) different protein of echinococcus granulosus stimulates dendritic induced immune response. parasitology 142:879-89.
zhang, y., zhang, l., ji, x., pang, m., ju, f., zhang, j., li, w., zhang, s., he, z., gan, w.b. & tang, p. (2015) two-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury model. restorative neurology and neuroscience 33:291-300.
liu, c.j., du, b., liu, n.f., bao, s.j. & zhang, s. (2014) sex-specific parental care strategies via nestling age: females pay more attention to nestling demands than males do in the horned lark, eremophila alpestris. zoological science 31:348-52.
li, t., pang, s., yu, y., wu, x., guo, j. & zhang, s. (2013) proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. brain 136:3578-88.
wang, j., feng, x., du, y., wang, l. & zhang, s. (2013) combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice. restorative neurology and neuroscience 31:487-99.
lu, b., li, t., zhao, h., li, x., gao, c., zhang, s. & xie, e. (2012) graphene-based composite materials beneficial to wound healing. nanoscale 4:2978-82.
zhang, s., wang, j. & wang, l. (2010) structural plasticity of dendritic spines. frontiers in biology 5:48-58.
bhatt, d.h., zhang, s. & gan, w.b. (2009) dendritic spine dynamics. annual review of physiology 71:261-82.
zhang, s. & murphy, t.h. (2007) imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. plos biology 5:e119.
enright, l.e., zhang, s. & murphy, t.h. (2007) fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer v neuron dendritic tufts within single neurons in vivo. journal of cerebral blood flow and metabolism 27:1185-200.
zhang, s., boyd, j., delaney, k. & murphy, t.h. (2005) rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. journal of neuroscience 25:5333-8.
zhang, s. & murphy, t.h. (2004) ca(2 )-independent spine dynamics in cultured hippocampal neurons. molecular and cellular neurosciences 25:334-44.
