苟小平 (dr. xiaoping gou)-凯发k8娱乐

（1）受体激酶介导的细胞信号转导。受体激酶（rlks）分布在细胞表面，从胞外环境获取信号并传递到细胞内启动下游的基因表达和调控，从而让植物体对各种信号作出正确的反应。在拟南芥中有600个以上的受体激酶，到目前为止只对其中很少一部分基因的功能有所了解。我们目前正通过反向遗传学的方法来解析这些受体激酶的生物学功能，尤其是那些可能参与调控拟南芥和玉米生殖发育过程的受体激酶的功能。

functional analysis of receptor kinases

there are more than 600 receptor-like kinases (rlks) in arabidopsis that locate on the surface of cells to perceive and transduce chemical signals into cells, regulating downstream gene expression and responding to a variety of biotic or abiotic stimuli. so far, biological functions have been defined for only a handful of rlks that play crucial roles in many physiological processes in plant. my research is focusing on revealing the functions of these rlks in arabidopsis and maize. preliminary studies showed that gene members of a couple of rlk subfamilies regulate anther and ovary development, and zygotic embryogenesis, which is under intensive investigation.

（2）植物生殖生物学。被子植物双受精是一个复杂的过程，一个精细胞与卵细胞融合形成合子，发育成胚胎，是下一代植物的雏形；另一个精细胞与中央细胞融合形成胚乳，为胚胎发育提供营养。双受精的成败关系到植物种群的延续，同时也关系到绝大部分农作物的产量与质量。实验室目前的工作主要是研究拟南芥和玉米雌雄生殖器官与性细胞发育调控的分子机理，以及早期胚胎发育调控的信号途径。

plant reproductive biology

double fertilization is a very complex biological process of angiosperms. after transferred into embryo sac by pollen tube, one sperm cell fuses with the egg cell, forming the zygote that will develop into the embryo, and the other sperm cell fuses with the center cell to generate the endosperm that provides nutrients for embryo development. successful double fertilization is critical for the survival and development of every species, and is also crucial for the quantity and quality of the production of many crops. plants have complex regulatory systems to regulate the development of sexual organs to achieve successful double fertilization and embryogenesis. my current research is focusing on those genes involved in anther, ovule and embryo development in arabidopsis and maize.

实验室得到国家自然科学基金委员会、教育部、科技部和兰州大学的经费支持。

1、主持项目：

国家自然科学基金面上项目：《拟南芥富含亮氨酸重复类受体激酶调控合子胚胎发育的分子机理》（no.31070283）、《拟南芥珠被发育的信号网络与调控机理》（no.31270229）、《pzipt1在拟南芥精细胞中表达的分子机理研究》（no.31471402）、《受体激酶ciks调控拟南芥根端分生组织稳态的分子机理》（31770312）

教育部新世纪优秀人才支持计划项目《受体激酶调控花药发育的分子机理》（no. ncet-12-0249）

教育部科学技术项目《受体激酶serks调控拟南芥胚胎发育的信号通路》（no.113058a）

2、参加项目：

国家自然科学基金重大研究计划重点项目《一类植物特有的转录因子tcp在油菜素内酯生物合成及信号转导中的调控机理》（no.90917019）

教育部“长江学者和创新团队发展计划”创新团队项目《植物多重抗逆的分子机理》（nos.irt0924, irt_13r25）

科技部重大科学研究计划课题《植物蛋白的修饰的重要过程与调控机理》（no.2011cb9154001）

教育部新世纪优秀人才支持计划（2012）

1、研究生（master and ph.d. programs）：

欢迎报考博士、硕士研究生。

博士研究生，招生专业：植物学（071001）；研究方向：植物分子遗传学、植物分子发育生物学、植物生殖生物学

硕士研究生，招生专业：植物学（071001）；研究方向：植物分子生物学、植物分子发育生物学、植物细胞信号转导

目前指导博士研究生10人，硕士研究生5人。

major for master students: plant biology (plant molecular biology, plant developmental biology, plant cell signaling)

major for ph.d. students: plant biology (plant molecular genetics, plant developmental biology, plant reproductive biology)

2、博士后（postdoctoral associate）:

欢迎新近毕业博士合作开展博士后研究工作，兰州大学提供师资博士后以及青年研究员工作岗位。

3、教学（teaching）：

植物生殖与发育生物学（秋季，本科生）／plant reproductive & developmental biology (fall, undergraduate)

植物生殖生物学（秋季，研究生）／plant reproductive biology (fall, graduate)

分子克隆与基因工程（秋季，研究生）／molecular cloning & genetic engineering (fall, graduate)

本科生科研训练（本科生）／independent study courses in plant biology (spring/fall, undergraduate)

# first author; * corresponding author.

wenping wang^#, chong hu^#, xiaonan li, yafen zhu, liang tao, yanwei cui, dingqian deng, xiaoxuan fan, hong zhang, jia li, xiaoping gou^*, jing yi^*. (2022). receptor-like cytoplasmic kinases pbl34/35/36 are required for cle peptide-mediated signaling to maintain sam and ram homeostasis in arabidopsis. plant cell, doi: 10.1093/plcell/koab315.

chong hu^#, yafen zhu^#, yanwei cui, li zeng, sunjingnan li, fanhui meng, shuting huang, wenping wang, hong kui, jing yi, jia li, dongshi wan, xiaoping gou^*. (2022). a cle–bam–cik signaling module controls root protophloem differentiation in arabidopsis. new phytologist, 233(1): 282-296. 

hong zhang, xiaonan li, wenping wang, huiqiang li, yanwei cui, yafen zhu, hong kui, jing yi, jia li, xiaoping gou^*. (2022). serks regulate embryonic cuticle integrity through the tws1-gso1/2 signaling pathway in arabidopsis. new phytologist, 233(1): 313-328.

yafen zhu^#, chong hu^#, yanwei cui, li zeng, sunjingnan li, mingsong zhu, fanhui meng, shuting huang, li long, jing yi, jia li, xiaoping gou^*. (2021). conserved and differentiated functions of cik receptor kinases in modulating stem cell signaling in arabidopsis. molecular plant, 14 (7): 1119-1134.

liang chen, mingfeng zhao, zhongliang wu, sicheng chen, enrique rojo, jiangwei luo, ping li, lulu zhao, yan chen, jianming deng, bo cheng, kai he, xiaoping gou, jia li and suiwen hou^*. (2020). rna polymerase ii associated proteins regulate stomatal development through direct interaction with stomatal transcription factors in arabidopsis thaliana. new phytologist, 230 (1): 171-189.

xiaoting lu, hongyong shi, yang ou, yanwei cui, jinke chang, liang peng, xiaoping gou, kai he, jia li^*. (2020). rgf1-rgi1, a peptide-receptor complex, regulates arabidopsis root meristem development via a mpak signaling cascade. molecular plant, 13: 1594-1607.

xun q, wu y, li h, chang j, ou y, he k, gou x, tax fe, li j. (2020). two receptor-like protein kinases, mustaches and mustaches-like, regulate lateral root development in arabidopsis thaliana. new phytologist, 227: 1157-1173.

gou x, li j. (2020). paired receptor and coreceptor kinases perceive extracellular signals to control plant development. plant physiology 182, 1667-1681.

chang j, li x, fu w, wang j, yong y, shi h, ding z, kui h, gou x, he k, li j. (2019). asymmetric distribution of cytokinins determines root hydrotropism in arabidopsis thaliana. cell research 29, 984-993.

chen w, lv m, wang y, wang pa, cui y, li m, wang r, gou x, li j. (2019). bes1 is activated by ems1-tpd1-serk1/2-mediated signaling to control tapetum development in arabidopsis thaliana. nature communications 10, 4164.

li h, cai z, wang x, li m, cui n, he k, yi j, tax fe, hou s, li j, gou x^*. (2019). serk receptor-like kinases control division patterns of vascular precursors and ground tissue stem cells during embryo development in arabidopsis. molecular plant 12, 984-1002.

wu z, chen l, yu q, zhou w, gou x, li j, hou s. (2019). multiple transcriptional factors control stomata development in rice. new phytologist 223, 220-232.

cui y, hu c, zhu y, cheng k, li x, wei z, xue l, lin f, shi h, yi j, hou s, he k, li j, gou x^*. (2018). cik receptor kinases determine cell fate specification during early anther development in arabidopsis. plant cell 30, 2383-2401. (cover story)

hu c, zhu y, cui y, cheng k, liang w, wei z, zhu m, yin h, zeng l, xiao y, lv m, yi j, hou s, he k, li j, gou x^*. (2018). a group of receptor kinases are essential for clavata signaling to maintain stem cell homeostasis. nature plants 4, 205-211. (cover story)

wei z, yuan t, tarkowská d, kim j, nam hg, novák o, he k, gou x, and li j. (2017). brassinosteroid biosynthesis is modulated via a transcription factor cascade of cog1, pif4 and pif5. plant physiology 174, 1260-1273.

ou y, lu x, zi q, xun q, zhang j, wu y, shi h, wei z, zhao b, zhang x, he k, gou x, li c and li j. (2016). rgf1 insensitive 1 to 5, a group of lrr receptor-like kinases, are essential for the perception of root meristem growth factor 1 in arabidopsis thaliana. cell research 26, 686-698.

chen l, guan l, qian p, xu f, wu z, wu y, he k, gou x, li j, hou s. (2016). nrpb3, the third largest subunit of rna polymerase ii, is essential for correct stomatal patterning and terminal differentiation in arabidopsis. development 143, 1600-1611.

zhang j, yuan t, duan x, wei x, li j, russell sd^*, gou x^*. (2016). cis-regulatory elements determine germline specificity and expression level of an isopentenyltransferase gene in sperm cells of arabidopsis. plant physiology 170, 1524-1534.

yue j, qin q, meng s, jin h, gou x, li j, hou s. (2016). topp4 regulates the stability of phytochrome interacting factor 5 during photomorphogenesis in arabidopsis. plant physiology 170, 1381-1397.

du j, gao y, zhan y, zhang s, wu y, xiao y, zou bo, he k, gou x, li g, lin h, li j. (2016). nucleocytoplasmic trafficking is essential for bak1 and bkk1-mediated cell-death control. plant journal 85, 520-531.

wu y, xun q, guo y, zhang j, cheng k, shi t, he k, hou s, gou x, li j. (2016) genome-wide expression pattern analyses of the arabidopsis leucine-rich repeat receptor-like kinases. molelular plant 9, 289-300.

anderson s, johnson c, jones d, conrad l, gou x, russell sd, sundaresan v. (2013). transcriptomes of isolated rice gametes characterized by deep sequencing: evidence for distinct sex-dependent chromatin and epigenetic states before fertilization. plant journal 76, 729-741.

russell sd, gou x, wong ce, wang xk, yuan t, wei xp, bhalla pl, singh mb. (2012). genomic profiling of rice sperm cell transcripts reveals conserved and distinct elements in the flowering plant male germ lineage. new phytologist 195, 560-573.

gou x^#, yin h^#, he k^#, du j, yi j, xu s, lin h, clouse sd, li j. (2012). genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. plos genetics 8, e1002452. 

guo z, fujioka s, blancaflor eb, miao s, gou x, li j. (2010). tcp1 controls brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene dwarf4 in arabidopsis thaliana. plant cell 22, 1161-1173.

gou x, yuan t, wei x, russell sd. (2009). gene expression in the dimorphic sperm cells of plumbago zeylanica: transcript profiling, diversity, and relationship to cell type. plant journal 60, 33-47.

he k, gou x, yuan t, lin h, asami t, yoshida s, russell sd, li j. (2007). bak1 and bkk1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. current biology 17, 1109-1115.