吉尚戎-凯发k8娱乐

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学习经历
■ 1994.9-1998.7,北京大学医学部,获理学学士学位;
■ 1998.9-2003.7,清华大学生物科学与技术系,获理学博士学位。
工作经历
■ 2003.9至今,兰州大学生命科学学院,教学科研。
社会工作
研究方向
■ 重要蛋白质参与慢性炎症疾病调控的分子机制
■ 蛋白质的结构/功能、膜脂-蛋白相互作用。
项目成果
■ 国家自然科学基金重点项目1项,面上项目15项;
■ 国家自然科学基金优秀青年基金1项;
■ 国家自然科学基金国际合作项目2项;
■ 教育部新世纪优秀人才支持计划2项;
■ 教育部博士点基金3项;
■ 教育部科技研究重点项目1
■ fei合作研究基金1项;
■ 兰州大学人才引进专项2
荣誉、获奖
■ 清华大学优秀博士学位论文二等奖,2003;
■ 国家自然科学二等奖(5/5),2005;
■ 教育部新世纪优秀人才支持计划,2007。
教学及指导研究生情况

  研究团队教授2人、副教授2人,研究生14人。

 

发表论文及专著

[1] cheng b., lv j.-m., liang y.-l., zhu l., huang x.-p., li h.-y., potempa l.a., ji s.-r.*, wu y.* (2022) secretory quality control constrains functional selection-associated protein structure innovationcommunications biology, 5: 268. (if 6.268)

[2] li h.-y., tang z.-m., wang z., lv j.-m., liu x.-l., liang y.-l., cheng b., gao n., ji s.-r. *, wu y.* (2022) c-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivationcellular and molecular gastroenterology and hepatology, 13(1): 289-307. (if 9.225)

[3] zhang s.-c., wang m.-y., feng j.-r., chang y., ji s.-r. *, wu y.* (2020) reversible promoter methylation determines fluctuating expression of acute phase proteins. elife, 9: e51317. (if 8.14)

[4] zhang l., shen z.-y., wang k., li w., shi j.-m., osoro e.k., ullah n., zhou y., ji s.-r. * (2019) c-reactive protein exacerbates epithelial-mesenchymal transition through wnt/b-catenin and erk signaling in streptozocin-induced diabetic nephropathy. faseb journal, 33(5): 6551-6563. (if 5.191)

[5] li h.-y., liu x.-l., liu y.-t., jia z.-k., filep j.g., potempa l.a., ji s.-r. *, wu y.* (2019) matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of c-reactive protein. cardiovascular research, 115(2): 440-452. (if 10.787)

[6] shi j.-m., lv j.-m., gao b.-x., zhang l.*, ji s.-r. * (2019) endosomal ph favors shedding of membrane-inserted amyloid-β peptide. protein science, 28(3): 889-899. (if 6.725)

[7] zhang l., li h.-y., li w., shen z.-y., wang y.-d., ji s.-r. *, wu y.* (2018) an elisa assay for quantifying monomeric c-reactive protein in plasma. frontiers in immunology, 9: 511. (if 7.561)

[8] jia z.-k., li h.-y., liang y.-l., potempa l.a., ji s.-r.*, wu y.* (2018) monomeric c-reactive protein binds and neutralizes rankl-induced osteoclast differentiation. frontiers in immunology, 9: 234. (if 7.561)

[9] lv j.-m., lv s.-q., liu z.-p., zhang j., gao b.-x., yao z.-y., wu y.-x., potempa l.a., ji s.-r.*, long m.*, wu y.* (2018) conformational folding and disulfide bonding drive distinct stages of protein structure formation. scientific reports, 8: 1494. (if 4.379)

[10] li h.-y., wang j., meng f., jia z.-k., su y., bai q.-f., lv l.-l., ma f.-r., potempa l.a., ji s.-r.*, wu y.* (2016) an intrinsically disordered motif mediates diverse actions of monomeric c-reactive protein. journal of biological chemistry, 291 (16): 8795-8804. (if 5.157)

[11] zhang l., liu s.-h., wright t.t., shen z.-y., li h.-y., zhu w., potempa l.a., ji s.-r.*, szalai a.j.*, wu y.* (2015) c-reactive protein directly suppresses t helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. journal of immunology, 194 (11): 5243-5252. (if 5.422)

[12] su h.-x., zhou h.-h., wang m.-y., cheng j., zhang s.-c., hui f., chen x-z, liu s.-h., liu q.-j., zhu z.-j., hu q.-r., wu y.*, ji s.-r.* (2014) mutations of c-reactive protein (crp) -286 snp, apc and p53 in colorectal cancer: implication for a crp-wnt crosstalk. plos one, 9 (7): e102418. (if 3.24)

[13] li h.-y., wang j., wu y.-x., zhang l., liu z.-p., filep j.g., potempa l.a., wu y.*, ji s.-r.* (2014) topological localization of monomeric c-reactive protein determines pro-inflammatory endothelial cell responses. journal of biological chemistry, 289 (20): 14283-14290. (if 5.157)

[14] wang m.-y., zhou h.-h., zhang s.-c., hui f., zhu w., su h.-x., guo h.-y., li x.-w., ji s.-r.*, wu y.* (2014) recurrent mutations at c-reactive protein promoter snp position -286 in human cancers. cell research, 24(4): 505-508. (if 25.617)

[15] zhang y.-j., shi j.-m., bai c.-j., wang h., li h.-y., wu y.*, ji s.-r.* (2012) intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. journal of biological chemistry, 287(1): 748-756. (if 5.157)

[16] wang m.-y., ji s.-r., bai c.-j., el kebir d., li h.-y., shi j.-m., zhu w., costantino s., zhou h.-h., potempa l.a., zhao j., filep j.g.*, wu y.* (2011) a redox switch in c-reactive protein modulates activation of endothelial cells. faseb journal, 25(9): 3186-3196. (if 5.191)

[17] zhu l., chen l., zhou x.-m., zhang y.-y., zhang y.-j., zhao j., ji s.-r., wu j.-w.*, wu y.* (2011) structural insights into the architecture and allostery of full-length amp-activated protein kinase. structure, 19(4): 515-522. (if 5.006)

[18] liu r.-q., zhou q.-h., ji s.-r., zhou q., feng d., wu y., sui s.-f.* (2010) membrane localization of β-amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. journal of biological chemistry, 285(26): 19986-19996. (if 5.157)

[19] ji s.-r., ma l., bai c.-j., shi j.-m., li h.-y., filep j.g., potempa l.a., zhao j., wu y.* (2009) monomeric c-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. faseb journal, 23(6): 1806-1816. (if 5.191)

[20] ji s.-r., wu y.*, zhu l., potempa l.a., sheng f.-l., lu w., zhao j. (2007) cell membranes and liposomes dissociate c-reactive protein (crp) to form a new, biologically active structural intermediate: mcrpm. faseb journal, 21(1): 284-294. (if 5.191)

[21] ji s.-r., wu y.*, potempa l.a., liang y.-h., zhao j. (2006) effect of modified c-reactive protein on complement activation: a possible complement regulatory role of mcrp in atherosclerotic lesions. arteriosclerosis, thrombosis, and vascular biology, 26(4): 935-941. (if 8.311)

[22] ji s.-r., wu y.*, potempa l.a., qiu q., zhao j. (2006) interactions of c-reactive protein with low density lipoproteins: implications of an active role of modified c-reactive protein in atherosclerosis. international journal of biochemistry & cell biology, 384(4): 648-661. (if 5.085)

[23] wu y., he y., bai j., ji s.-r., tucker w.c., chapman e.r.*, sui s.-f.* (2003) visualization of synaptotagmin i oligomers assembled on lipid monolayers. proceedings of the national academy of sciences of the united states of america, 100(4): 2082-2087. (if 11.205)

[24] ji s.-r., wu y., sui s.-f.* (2002) cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (abeta 1-40), which may potentially inhibit the fibril formation. journal of biological chemistry, 277(8): 6273-6279. (if 5.157)

[25] wu y., wang h.-w., ji s.-r., sui s.-f.* (2003) two-dimensional crystallization of rabbit c-reactive protein monomeric subunits. acta crystallographica section d-biological crystallography59(5): 922-926. (if 7.652)

 

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