牟凌云-凯发k8娱乐

课题组目前主要从事以g蛋白偶联受体为靶点的生物活性多肽在肿瘤发生发展过程的作用机制研究。

（一）g蛋白偶联受体在肿瘤细胞中的多信号转导机制及其在肿瘤生长转移中的调控作用；

（二）靶向g蛋白偶联受体的新型肿瘤治疗药物研究；

（三）非天然氨基酸在多肽药物构效关系研究中的应用。

1. 国家自然科学基金面上项目，nk1受体调控前列腺癌神经内分泌转分化及其作为新型抗肿瘤靶点的研究
2. 国家自然科学青年基金，速激肽受体neurokinin-1功能选择性及其在肿瘤细胞增殖迁移中的作用
3. 甘肃省科技支撑计划，新型 nk1 受体拮抗剂的设计合成及其靶向抗肿瘤生物活性的研究
4. 国家自然科学基金重大研究计划集成项目，基于化学小分子探针的信号转导过程研究— 基于配体调控的核酸相关信号通路研究方向，子项目 (主要参与人)
5. 国家自然科学基金重大研究计划集成项目，基于化学小分子探针的信号转导过程研究— 具有肿瘤靶向性的炔酸酯类探针分子化学构建及其调控端粒酶相关信号通路的研究，子项目(主要参与人)

2013年度，中国药学会科学技术奖一等奖，排名10/15

硕士生导师

承担本科生《生物化学》、《生物化学实验》、《多肽科学》课程。

1. miao x, zhou t, zhang j, xu j, guo x, hu h, zhang x, hu m, li j, yang w, xie j, xu z, mou l*. enhanced cell selectivity of hybrid peptides with potential antimicrobial activity and immunomodulatory effect. biochim biophys acta gen subj. 2020 apr;1864(4):129532.
2. hu h, miao xk, li jy, zhang xw, xu jj, zhang jy, zhou tx, hu mn, yang wl, mou ly*. yc-1 potentiates the antitumor activity of gefitinib by inhibiting hif-1α and promoting the endocytic trafficking and degradation of egfr in gefitinib-resistant non-small-cell lung cancer cells. eur j pharmacol. 2020 may 5;874:172961.
3. zhang yx, li xf, yuan gq, hu h, song xy, li jy, miao xk, zhou tx, yang wl, zhang xw, mou ly*, wang r. β-arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and g₂/m phase transition. j biol chem. 2017 may 26;292(21):8933-8947.
4. li j, zeng q, zhang y, li x, hu h, miao x, yang w, zhang w, song x, mou l*, wang r. neurokinin-1 receptor mediated breast cancer cell migration by increased expression of mmp-2 and mmp-14. eur j cell biol. 2016 oct;95(10):368-377.
5. zhang y, li x, li j, hu h, miao x, song x, yang w, zeng q, mou l*, wang r. human hemokinin-1 promotes migration of melanoma cells and increases mmp-2 and mt1-mmp expression by activating tumor cell nk1 receptors. peptides. 2016 sep;83:8-15.
6. mou l, kang y, zhou y, zeng q, song h, wang r. neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (mmp-2) and membrane type 1-matrix metalloproteinase (mt1-mmp). j biol chem. 2013 jan 4;288(1):306-18.
7. mou l, xing y, kong z, zhou y, chen z, wang r. the n-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1. biochem pharmacol. 2011 mar 1;81(5):661-8.
8. yan z, wang d, an c, xu h, zhao q, shi y, song n, deng b, guo x, rao j, cheng l, zhang b, mou l, yang w, jiang x, xie j. the antimicrobial peptide yd attenuates inflammation via mir-155 targeting casp12 during liver fibrosis. acta pharm sin b. 2021 jan;11(1):100-111.
9. xie j, li y, guo x, rao j, yan t, mou l, wu x, xie x, yang w, zhang b. cpf-c1 analog with effective antimicrobial and antibiofilm activities against staphylococcus aureus including mrsa. biochimie. 2020 sep;176:1-11.
10. li g, zhao m, xie j, yao y, mou l, zhang x, guo x, sun w, wang z, xu j, xue j, hu t, zhang m, li m, hong l. efficient synthesis of cyclic amidine-based fluorophores via 6π-electrocyclic ring closure. chem sci. 2020 mar 13;11(14):3586-3591.
11. xie j, li y, li j, yan z, wang d, guo x, zhang j, zhang b, mou l, yang w, jiang x. potent effects of amino acid scanned antimicrobial peptide feleucin-k3 analogs against both multidrug-resistant strains and biofilms of pseudomonas aeruginosa. amino acids. 2018 oct;50(10):1471-1483.
12. xie j, gou y, zhao q, li s, zhang w, song j, mou l, li j, wang k, zhang b, yang w, wang r. antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria. j pept sci. 2015 jul;21(7):599-607.
13. liu x, zhao l, wang y, zhou j, wang d, zhang y, zhang x, wang z, yang d, mou l, wang r. mel-n16: a series of novel endomorphin analogs with good analgesic activity and a favorable side effect profile. acs chem neurosci. 2017 oct 18;8(10):2180-2193.
14. wang y, yang j, liu x, zhao l, yang d, zhou j, wang d, mou l, wang r. endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration. org biomol chem. 2017 jun 14;15(23):4951-4955.
15. liu x, zhao l, wang y, mou l, yang j, zhang y, wang d, wang r. design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration. bioorg med chem lett. 2015 nov 15;25(22):5393-7.
16. song h, yin w, zeng q, jia h, lin l, liu x, mu l, wang r. hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor. int j biochem cell biol. 2012 sep;44(9):1410-21.
17. zhang w, song j, mu l, zhang b, liu l, xing y, wang k, li z, wang r. improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance p. bioorg med chem lett. 2011 mar 1;21(5):1452-5.
18. jinghong jiang, zheng he, yali peng, weidong jin, z wang, lingyun mou, ming chang*, rui wang*. phoenixin-14 enhances memory and mitigates memory impairment induced by aβ1-42 and scopolamine in mice. brain res., 1629:298-208, 2015.