向云-凯发k8娱乐

    微丝骨架（actin cytoskeleton）是遍布于一切真核细胞中的三维网状结构，占植物总蛋白的15-20%，在维持细胞形态、参与细胞运动、胞质分裂和极性建立等重要细胞生理活动中起着决定性的作用。微丝骨架的动态变化是其行使各种生理功能的基础，而该过程则直接受到诸多微丝结合蛋白和不同信号分子的调控。本课题组以模式作物拟南芥为材料，主要开展如下研究工作：

1. 探索植物特有的、功能未知的微丝结合蛋白；

2. 微丝骨架参与植物花粉管极性生长的分子机理；

3. 微丝骨架参与植物响应各种非生物胁迫的分子机理；

4. 植物抗逆信号转导（钙离子）。

1. 国家自然科学基金-面上项目，31970195，拟南芥p4-atpase的β亚基成员alis1/3调控根发育的功能研究，2020/01-2023/12，在研，主持

2. 国家自然科学基金-优秀青年科学基金项目，31722005，植物细胞骨架，2018/01-2020/12，在研，主持

3. 国家自然科学基金-面上项目，31670180，拟南芥微丝解聚因子第三亚家族成员生理生化功能研究，2017/01-2020/12，在研，主持

4. 国家自然科学基金-面上项目，31470283，拟南芥微丝交联蛋白crolins调控花粉管生长的分子机理研究，2015/01-2018/12，在研，主持

5. 教育部"新世纪优秀人才支持计划"，ncet-13-0264，植物细胞骨架，2014/01-2015/12，已结题，主持

6. 国家自然科学基金-面上项目，31270326，拟南芥液泡氢atp酶b亚基不同异形体的生理生化功能及作用机理研究，2013/01-2016/12，已结题，主持

7. 甘肃省杰出青年基金，2013gs10064，微丝骨架参与植物响应干旱和高盐胁迫分子机理研究，2013/01-2015/12，已结题，主持

8. 国家自然科学基金-青年科学基金，30800079，拟南芥膜联蛋白annexin5调控花粉管极性生长的分子机制研究，2009/01-2011/12，已结题，主持

1. 国家优秀青年基金（2017）

2. 教育部“长江学者奖励计划”青年学者（2017）

2. 教育部"新世纪优秀人才支持计划"（2013）

3. 甘肃省杰出青年基金（2013）

*代表通讯作者，#代表共同第一作者

[1] yuelong zhou^#, yang yang^#, yue niu^#, tingting fan, dong qian, changxin luo, yumei shi, shanwei li, lizhe an, yun xiang*. the tip-localized phosphatidylserine established by arabidopsis ala3 is crucial for rab gtpase-mediated vesicle trafficking and pollen tube growth. plant cell, 2020, 32: 3170-3187.

[2] dong qian^* and yun xiang. (2019) actin cytoskeleton as actor in upstream and downstream of calcium signaling in plant cells. international journal of molecular sciences, 2019, 20: 1403.

[3]钱东，李盼盼，向云*.微丝骨架调控植物特有生理活动的研究进展.中国细胞生物学学报, 2019, 41: 399–405. (创刊四十周年专栏·细胞骨架)

[4] dong qian, zhe zhang, juanxia he, pan zhang, xiaobin ou, tian li, lipan niu, qiong nan, yue niu, wenliang he, lizhe an, kun jiang, and yun xiang^*. arabidopsis adf5 promotes stomatal closure by regulating actin cytoskeleton remodeling in response to aba and drought stress. journal of experimental botany, 2019, 70: 435–446.

[5] yue niu* and yun xiang*. an overview of biomembrane functions in plant responses to high-temperature stress. frontiers in plant science, 2018, 9: 915.

[6] 钱东，向云*. 植物特有微丝结合蛋白研究进展.中国科学：生命科学. 2017, 47: 829-838.（兰州大学专刊）

[7] yue niu*, dong qian, baiyun liu, jianchao ma, dongshi wan, xinyu wang, wenliang he, yun xiang*. ala6, a p4-type atpase, is involved in heat stress responses in arabidopsis thaliana. frontiers in plant science, 2017, 8: 1732.

[8] hui su*, hualing feng, xiaoting chao, xia ding, qiong nan, chenxi wen, huidong liu, sinuo liu, yun xiang*, wenzhe liu*, fimbrins 4 and 5 act synergistically during polarized pollen-tube growth to ensure fertility in arabidopsis. plant and cell physiology, 2017, 58: 2006-2016.

[9] jingen zhu^#, qiong nan^#, tao qin^#, dong qian, tonglin mao, shunjie yuan, xiaorong wu, yue niu, qifeng bai, lizhe an, yun xiang*, higher-ordered actin structures remodeled by arabidopsis actin-depolymerizing factor5 are important for pollen germination and pollen tube growth. molecular plant, 2017, 10: 1065-1081.

[10] qiong nan^#, dong qian^#, yue niu, yongxing he, shaofei tong, zhimin niu, jianchao ma, yang yang, lizhe an, dongshi wan*, yun xiang*, plant actin-depolymerizing factors possess opposing biochemical properties arising from key amino acid changes throughout evolution. plant cell, 2017, 29(2): 395-408. (highlighted paper by science editor in “in brief” )

• jennifer lockhart, loose-knit family: tracing the evolution of actin-depolymerizing factors that sever or join the actin cytoskeleton. plant cell, 2017, 29 (2): 200-201, doi: https://doi.org/10.1105/tpc.17.00088.

[11] jiangtao liu, yuelong zhou, changxin luo, yun xiang, lizhe an*, de novo transcriptome sequencing of desert herbaceous achnatherum splendens (achnatherum) seedlings and identification of salt tolerance genes. genes, 2016, 23: 7(4): 12.

[12] hui wang, shengcheng han, wei siao, chunqing song, yun xiang, xiaorong wu, pengyu cheng, hongjuan li, ján jásik, karol mičieta, ján turňa, boris voigt, františek baluška, jin liu, yingdian wang, heping zhao*, arabidopsis synaptotagmin 2 participates in pollen germination and tube growth and is delivered to plasma membrane via conventional secretion. molecular plant, 2015, 8(12):1737-1750.

[13] dong qian, qiong nan, yang yang, hui li, yuelong zhou, jingen zhu, qifeng bai, pan zhang, lizhe an, yun xiang*, gelsolin-like domain 3 plays vital roles in regulating the activities of the lily villin/gelsolin/fragmin superfamily. plos one, 2015, 10(11): e0143174.

[14] jingen zhu, xiaorong wu, shunjie yuan, dong qian, qiong nan, lizhe an, yun xiang* (2014) annexin5 plays a vital role in arabidopsis pollen development via ca² -dependent membrane trafficking. plos one, 2014, 9(7): e102407.

[15] jingen zhu, shunjie yuan, guo wei, dong qian, xiaorong wu, honglei jia, mengyuan gui, wenzhe liu, lizhe an*, yun xiang*, annexin5 is essential for pollen development in arabidopsis. molecular plant, 2014, 7(4): 751-754.

[16] honglei jia, jisheng li, jingen zhu, tingting fan, dong qian, yuelong zhou, jue wang, haiyun ren, yun xiang*, lizhe an*, arabidopsis crolin1, a novel plant actin-binding protein, functions in cross-linking and stabilizing actin filaments. journal of biological chemisty, 2013, 288: 32277-32288.

[17] tingting fan, huanhuan zhai, wenwei shi, jue wang, honglei jia, yun xiang*, lizhe an*, overexpression of profilin 3 affects cell elongation and f-actin organization in arabidopsis thaliana. plant cell reports, 2013, 32(1): 149-160.

[18] binyun ma, dong qian, qiong nan, chang tan, lizhe an*, yun xiang*, arabidopsis v-atpase b subunits are involved in actin cytoskeleton remodeling via binding to, bundling and stabilizing f-actin. journal of biological chemisty, 2012, 287: 19008-19017.

[19] jue wang, dong qian, tingting fan, honglei jia, lizhe an*, yun xiang*, arabidopsis actin capping protein (atcp) subunits have different expression patterns, and downregulation of atcpb confers increased thermotolerance of arabidopsis after heat shock stress. plant science, 2012, 193: 110-119.

[20] shanjin huang, yun xiang, haiyun ren. (2011). actin-binding proteins and actin dynamics in plant cells. in the plant cytoskeleton, 2011, pp. 57-80. springer new york.

[21] binyun ma, yun xiang, lizhe an*, structural bases of physiological functions and roles of the vacuolar h -atpase. cellular signalling, 2011, 23: 1244-1256.

[22] ting wang^#, yun xiang^#, jian hou, haiyun ren*, abp41 is involved in the pollen tube development via fragmenting actin filaments. molecular plant, 2008, 1(6): 1048-1055.

[23] yun xiang, xi huang, ting wang, yan zhang, qinwen liu, patrick j hussey, haiyun ren*, actin binding protein29 from lilium pollen plays an important role in dynamic actin remodeling. plant cell, 2007, 19(6): 1930-1946.

[24] haiyun ren*, yun xiang, the function of actin-binding proteins in pollen tube growth. protoplasma, 2007, 230(3-4): 171-182.